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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL1087908
Molecular formula	C26H23FN4O2
IUPAC name	[(2S)-4-(3-fluoro-4-pyridin-4-ylbenzoyl)-2-methylpiperazin-1-yl]-(1H-indol-6-yl)methanone
Molecular weight	442.494
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	1H-Indole-6-yl[(2S)-2beta-methyl-4-[3-fluoro-4-(4-pyridinyl)benzoyl]-1-piperazinyl] ketone (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-fluoro-4-(pyridin-4-yl)phenyl)methanone BDBM50312799
Inchi Key	XOLPBWFHVUUEEH-KRWDZBQOSA-N
Inchi ID	InChI=1S/C26H23FN4O2/c1-17-16-30(12-13-31(17)26(33)21-3-2-19-8-11-29-24(19)15-21)25(32)20-4-5-22(23(27)14-20)18-6-9-28-10-7-18/h2-11,14-15,17,29H,12-13,16H2,1H3/t17-/m0/s1
PubChem CID	46865987
ChEMBL	CHEMBL1087908
IUPHAR	N/A
BindingDB	50312799
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	-16.0 %	PMID20137933	ChEMBL
Activity	10.3 %	PMID20137933	ChEMBL

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