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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL210899
Molecular formula	C40H45N5O6
IUPAC name	N-benzyl-N-[3-[[3-(2-morpholin-4-ylethoxy)-N-(phenylcarbamoyl)anilino]methyl]cyclohexyl]-3-nitrobenzamide
Molecular weight	691.829
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	6.3
Synonyms	rac-1-((3-(N-benzyl-3-nitrobenzamido)cyclohexyl)methyl)-1-(3-(2-morpholinoethoxy)phenyl)-3-phenylurea BDBM50186104
Inchi Key	AEZJPJAVMUUMLW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C40H45N5O6/c46-39(33-13-8-18-37(27-33)45(48)49)43(29-31-10-3-1-4-11-31)35-16-7-12-32(26-35)30-44(40(47)41-34-14-5-2-6-15-34)36-17-9-19-38(28-36)51-25-22-42-20-23-50-24-21-42/h1-6,8-11,13-15,17-19,27-28,32,35H,7,12,16,20-26,29-30H2,(H,41,47)
PubChem CID	10122749
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50186104
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1160.0 nM	PMID16650762	BindingDB

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