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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Mus musculus (Mouse)
Gene	Trhr
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	N/A for non-human GPCRs
Length	393
Amino acid sequence	MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
UniProt	P21761
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2467
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Thyrotropin releasing hormone
Molecular formula	C16H22N6O4
IUPAC name	N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	362.39
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	-2.5
Synonyms	FDA 1725 NCGC00166322-01 Protirelina SMP2_000152 TRH AC1L1NDI BDBM86214 L-Pyroglutamyl-L-histidyl-L-prolinamide NSC_32281 Protirelinum [INN-Latin] Synthetic tsh-releasing hormone XNSAINXGIQZQOO-UHFFFAOYSA-N 1-[2-[(5-Oxo-2-pyrrolidinyl)carbonylamino]-3-(1H-imidazol-4-yl)propionyl]pyrrolidine-2-carboxamide CCRIS 2593 MCULE-5812782214 Protirelin [USAN:BAN:INN:JAN] Ro 8-6270/9 AKOS024284364 HMS3264O18 NSC-760113 Protirelina [INN-Spanish] ST075200 VA11870 CAS_32281 L001154 Pharmakon1600-01506101 pyro-Glu-His-Pro-NH2 Thyroid releasing hormone 1-[3-(1H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanoyl]pyrrolidine-2-carboxamide EINECS 246-143-4 N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Protirelin;Thyrotropin Releasing Hormone SCHEMBL8364920 Thyrotropin-releasing factor AB01563143_01 BCP12450 L-Prolinamide, 5-oxo-L-prolyl-L-histidyl- NSC760113 Protireline [INN-French] Synthetic tsh-releasing factor W-107333 CCG-213612 LS-118865 Phe2TRH PyroGLU-HIS-PRO AMIDE Thyrothropin relasing hormone 1-{3-imidazol-5-yl-2-[(5-oxopyrrolidin-2-yl)carbonylamino]propanoyl}pyrrolidin e-2-carboxamide [ Show all ]
Inchi Key	XNSAINXGIQZQOO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)
PubChem CID	32281
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86214
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.0 nM	PMID12697690	BindingDB
Ki	5400.0 nM	PMID12697690	BindingDB

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