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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Thyrotropin releasing hormone
Molecular formula	C16H22N6O4
IUPAC name	N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	362.39
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	-2.5
Synonyms	FDA 1725 NCGC00166322-01 Protirelina SMP2_000152 TRH AC1L1NDI BDBM86214 L-Pyroglutamyl-L-histidyl-L-prolinamide NSC_32281 Protirelinum [INN-Latin] Synthetic tsh-releasing hormone XNSAINXGIQZQOO-UHFFFAOYSA-N 1-[2-[(5-Oxo-2-pyrrolidinyl)carbonylamino]-3-(1H-imidazol-4-yl)propionyl]pyrrolidine-2-carboxamide CCRIS 2593 MCULE-5812782214 Protirelin [USAN:BAN:INN:JAN] Ro 8-6270/9 AKOS024284364 HMS3264O18 NSC-760113 Protirelina [INN-Spanish] ST075200 VA11870 CAS_32281 L001154 Pharmakon1600-01506101 pyro-Glu-His-Pro-NH2 Thyroid releasing hormone 1-[3-(1H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanoyl]pyrrolidine-2-carboxamide EINECS 246-143-4 N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide Protirelin;Thyrotropin Releasing Hormone SCHEMBL8364920 Thyrotropin-releasing factor AB01563143_01 BCP12450 L-Prolinamide, 5-oxo-L-prolyl-L-histidyl- NSC760113 Protireline [INN-French] Synthetic tsh-releasing factor W-107333 CCG-213612 LS-118865 Phe2TRH PyroGLU-HIS-PRO AMIDE Thyrothropin relasing hormone 1-{3-imidazol-5-yl-2-[(5-oxopyrrolidin-2-yl)carbonylamino]propanoyl}pyrrolidin e-2-carboxamide [ Show all ]
Inchi Key	XNSAINXGIQZQOO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)
PubChem CID	32281
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86214
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
396605	Thyrotropin-releasing hormone receptor	P21761	Trhr	Mus musculus (Mouse)	393

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