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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide S receptor
Species	Homo sapiens (Human)
Gene	NPSR1
Synonym	G-protein coupled receptor for asthma susceptibility vasopressin receptor-related receptor 1 G protein-coupled receptor 154 PGR14 NPS receptor G-protein coupled receptor 154 GPR154 G-protein coupled receptor PGR14 VRR1 [ Show all ]
Disease	Neurological disease
Length	371
Amino acid sequence	MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
UniProt	Q6W5P4
Protein Data Bank	N/A
GPCR-HGmod model	Q6W5P4
3D structure model	This predicted structure model is from GPCR-EXP Q6W5P4.
BioLiP	N/A
Therapeutic Target Database	T20958
ChEMBL	CHEMBL5162
IUPHAR	302
DrugBank	BE0000948

Ligand

Name	CHEMBL1441254
Molecular formula	C17H13ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-phenylpyridazin-3-one
Molecular weight	328.752
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.6
Synonyms	KS-000039SH SR-01000692203-3 AKOS005095267 MolPort-002-872-090 SMR000179332 5-chloro-4-(4-methoxyphenoxy)-2-phenyl-3(2H)-pyridazinone MCULE-9419118685 ZINC1023864 5M-594S BDBM50401588 Oprea1_367843 42190-48-7 HMS2310B11 SR-01000692203 5-chloro-4-(4-methoxyphenoxy)-2-phenylpyridazin-3-one MLS000326761 AC1MCSS9 REGID_for_CID_2800329 5-chloro-4-(4-methoxyphenoxy)-2-phenyl-2,3-dihydropyridazin-3-one [ Show all ]
Inchi Key	CDMJYZVKNAEVQP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H13ClN2O3/c1-22-13-7-9-14(10-8-13)23-16-15(18)11-19-20(17(16)21)12-5-3-2-4-6-12/h2-11H,1H3
PubChem CID	2800329
ChEMBL	CHEMBL1441254
IUPHAR	N/A
BindingDB	50401588
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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