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GPCR

NameN-arachidonyl glycine receptor
SpeciesHomo sapiens (Human)
GeneGPR18
SynonymGPCRW
G-protein coupled receptor 18
N-arachidonoyol glycine receptor
NAGly receptor
GPR18
DiseaseN/A
Length331
Amino acid sequenceMITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProtQ14330
Protein Data BankN/A
GPCR-HGmod modelQ14330
3D structure modelThis predicted structure model is from GPCR-EXP Q14330.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2384898
IUPHAR89
DrugBankBE0002304

Ligand

NameCHEMBL3221190
Molecular formulaC20H16Cl2N2O2S
IUPAC name(2Z)-2-[[3-[(2,4-dichlorophenyl)methoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one
Molecular weight419.32
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.3
Synonyms2-[3-(2,4-Dichlorobenzyloxy)benzylidene]-2,3,6,7-tetrahydro-5H-imidazo[2,1-b][1,3]thiazine-3-one
Inchi KeyXHZPDJWLDJSJEG-ZDLGFXPLSA-N
Inchi IDInChI=1S/C20H16Cl2N2O2S/c21-15-6-5-14(17(22)11-15)12-26-16-4-1-3-13(9-16)10-18-19(25)24-7-2-8-27-20(24)23-18/h1,3-6,9-11H,2,7-8,12H2/b18-10-
PubChem CID90667656
ChEMBLCHEMBL3221190
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %MedChemComm, (2014) 5:5:632ChEMBL
IC502550.0 nMMedChemComm, (2014) 5:5:632ChEMBL

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