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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Proteinase-activated receptor 2
Species	Rattus norvegicus (Rat)
Gene	F2rl1
Synonym	coagulation factor II (thrombin) receptor-like 1 coagulation factor II receptor-like 1 GPR11 PAR-2 PAR2 Protease-activated receptor-2 Thrombin receptor-like 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
UniProt	Q63645
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2429706
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	H-SER-PHE-LEU-LEU-ARG-NH2
Molecular formula	C30H51N9O6
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
Molecular weight	633.795
Hydrogen bond acceptor	8
Hydrogen bond donor	9
XlogP	-0.5
Synonyms	Ser-Phe-Leu-Leu-Arg-NH2 AKOS030525614 ZINC27076581 (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid [(S)-1-((S)-1-carbamoyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide CAS_141923-41-3 SFLLR-NH2 (S)-2-((S)-2-((S)-2-Amino-3-hydroxyPropanamido)-3-phenylPropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide BDBM50031381 141923-41-3 P5-NH2 THROMBIN RECEPTOR AGONIST,AMIDE (SFLLR - NH2) (S)-2-((S)-2-((S)-2-amino-3-hydroxypropanamido)-3-phenylpropanamido)-N-((S)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide BDBM85516 1N-[1-[4-amino(imino)methylamino-1-carbamoyl-(1S)-butylcarbamoyl]-3-methyl-(1S)-butyl]-2-[1-[1-amino-2-hydroxy-(1S)-ethylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-4-methyl-(2S)-pentanamide CHEMBL115543 [ Show all ]
Inchi Key	CDBPTZOOUNAWQA-LSBAASHUSA-N
Inchi ID	InChI=1S/C30H51N9O6/c1-17(2)13-22(27(43)36-21(25(32)41)11-8-12-35-30(33)34)38-28(44)23(14-18(3)4)39-29(45)24(37-26(42)20(31)16-40)15-19-9-6-5-7-10-19/h5-7,9-10,17-18,20-24,40H,8,11-16,31H2,1-4H3,(H2,32,41)(H,36,43)(H,37,42)(H,38,44)(H,39,45)(H4,33,34,35)/t20-,21-,22-,23-,24-/m0/s1
PubChem CID	9809471
ChEMBL	CHEMBL115543
IUPHAR	N/A
BindingDB	50031381, 85516
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2300.0 nM	PMID10411588	BindingDB

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