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GLASS

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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL3670649
Molecular formula	C26H28N4O5
IUPAC name	[3-[2-methoxy-4-(2-oxa-5-azaspiro[3.4]octan-5-ylmethyl)phenoxy]azetidin-1-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
Molecular weight	476.533
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	2.5
Synonyms	US8685958, 17 AABXIVRNFNDUCI-UHFFFAOYSA-N (3-(4-(2-oxa-5-azaspiro[3.4]octan-5-ylmethyl)-2-methoxyphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone BDBM119768 SCHEMBL14636078
Inchi Key	AABXIVRNFNDUCI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28N4O5/c1-32-22-12-18(13-30-11-5-10-26(30)16-33-17-26)8-9-21(22)34-20-14-29(15-20)25(31)24-28-27-23(35-24)19-6-3-2-4-7-19/h2-4,6-9,12,20H,5,10-11,13-17H2,1H3
PubChem CID	71225876
ChEMBL	CHEMBL3670649
IUPHAR	N/A
BindingDB	119768
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	420.0 nM	, None	BindingDB,ChEMBL

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