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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	Ghrp-6
Molecular formula	C46H56N12O6
IUPAC name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Molecular weight	873.032
Hydrogen bond acceptor	9
Hydrogen bond donor	11
XlogP	1.9
Synonyms	SK&F-110679 [D-Trp7, Ala8, D-Phe10]-\|A-Melanocyte Stimulating Hormone Amide Fragment 6-11 (D-Trp(2)-D-phe(5))ghrp AKOS028109152 FT-0650597 h-his-d-trp-ala-trp-d-phe-lys-nh2 KB-52247 UNII-4H7N4I6X6A 16G840 C46H56N12O6 Ghrp, his(1)-lys(6)- His-D-Trp-Ala-Trp-D-Phe-LysNH2 MFCD00872694 [D-Trp7, Ala8, D-Phe10]-alpha-Melanocyte Stimulating Hormone Amide Fragment 6-11 87616-84-0 CHEMBL105462 growth hormone releasing hexapeptide His-trp-ala-trp-phe-lysnh2 SCHEMBL9726175 Skf 110679 (S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(1H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide BDBM263227 GH-Releasing hexapeptide 6 His(1)-lys(6)-ghrp L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide US9708370, GHRP-6 4H7N4I6X6A CG-042 His-DTrp-Ala-Trp-DPhe-Lys-NH2 NCGC00167341-01 SK&F 110679 [D-Trp7, Ala8, D-Phe10]-alpha-Melanocyte Stimulating Hormone Amide Fragment 6-11, >=97% (HPLC) ABP000559 FT-0082558 Growth hormone releasing peptide Histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide Somatostatin Acetate/ (S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide BDBM50049479 GH-Releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl- ZINC150344347 GHRP-6 Acetate His-DTrp-Ala-Trp-DPhe-LysNH2 Q433 [ Show all ]
Inchi Key	WZHKXNSOCOQYQX-FUAFALNISA-N
Inchi ID	InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
PubChem CID	9919153
ChEMBL	CHEMBL105462
IUPHAR	N/A
BindingDB	50049479
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6.08 nM	PMID22712585	BindingDB,ChEMBL
IC50	6000.0 nM	PMID10636230	BindingDB,ChEMBL
Ki	6.0 nM	PMID8627599	BindingDB,ChEMBL

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