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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	Ghrp-6
Molecular formula	C46H56N12O6
IUPAC name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Molecular weight	873.032
Hydrogen bond acceptor	9
Hydrogen bond donor	11
XlogP	1.9
Synonyms	UNII-4H7N4I6X6A 16G840 C46H56N12O6 Ghrp, his(1)-lys(6)- His-D-Trp-Ala-Trp-D-Phe-LysNH2 MFCD00872694 [D-Trp7, Ala8, D-Phe10]-alpha-Melanocyte Stimulating Hormone Amide Fragment 6-11 87616-84-0 CHEMBL105462 growth hormone releasing hexapeptide His-trp-ala-trp-phe-lysnh2 SCHEMBL9726175 Skf 110679 (S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(1H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide BDBM263227 GH-Releasing hexapeptide 6 His(1)-lys(6)-ghrp L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide US9708370, GHRP-6 4H7N4I6X6A CG-042 His-DTrp-Ala-Trp-DPhe-Lys-NH2 NCGC00167341-01 SK&F 110679 [D-Trp7, Ala8, D-Phe10]-alpha-Melanocyte Stimulating Hormone Amide Fragment 6-11, >=97% (HPLC) ABP000559 FT-0082558 Growth hormone releasing peptide Histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide Somatostatin Acetate/ (S)-6-Amino-2-{(R)-2-[(S)-2-{(S)-2-[(R)-2-[(S)-2-amino-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid amide BDBM50049479 GH-Releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl- ZINC150344347 GHRP-6 Acetate His-DTrp-Ala-Trp-DPhe-LysNH2 Q433 SK&F-110679 [D-Trp7, Ala8, D-Phe10]-\|A-Melanocyte Stimulating Hormone Amide Fragment 6-11 (D-Trp(2)-D-phe(5))ghrp AKOS028109152 FT-0650597 h-his-d-trp-ala-trp-d-phe-lys-nh2 KB-52247 [ Show all ]
Inchi Key	WZHKXNSOCOQYQX-FUAFALNISA-N
Inchi ID	InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
PubChem CID	9919153
ChEMBL	CHEMBL105462
IUPHAR	N/A
BindingDB	50049479
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.7 nM	PMID9733496	ChEMBL
EC50	10.0 nM	PMID9925440	ChEMBL
Emax	100.0 %	PMID9733496	ChEMBL

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