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Name | Somatostatin receptor type 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | SSTR1 |
Synonym | SRIF-2 SS-1-R SS1-R SS1R SST1 receptor |
Disease | Alzheimer disease Cushing's disease Neuroendocrine cancer |
Length | 391 |
Amino acid sequence | MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL |
UniProt | P30872 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30872 |
3D structure model | This predicted structure model is from GPCR-EXP P30872. |
BioLiP | N/A |
Therapeutic Target Database | T16633 |
ChEMBL | CHEMBL1917 |
IUPHAR | 355 |
DrugBank | BE0000452 |
Name | BDBM84630 |
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Molecular formula | C56H66N10O9S2 |
IUPAC name | 10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-N-(naphthalen-1-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide |
Molecular weight | 1087.32 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 12 |
XlogP | 4.2 |
Synonyms | BIM 23060 |
Inchi Key | WVMBVVRMFHGKTH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C56H66N10O9S2/c1-33(67)49-56(75)65-47(51(70)60-29-37-16-11-15-36-14-5-6-17-40(36)37)31-76-77-32-48(64-50(69)42(58)26-34-12-3-2-4-13-34)55(74)62-45(27-35-21-23-39(68)24-22-35)53(72)63-46(28-38-30-59-43-19-8-7-18-41(38)43)54(73)61-44(52(71)66-49)20-9-10-25-57/h2-8,11-19,21-24,30,33,42,44-49,59,67-68H,9-10,20,25-29,31-32,57-58H2,1H3,(H,60,70)(H,61,73)(H,62,74)(H,63,72)(H,64,69)(H,65,75)(H,66,71) |
PubChem CID | 57339795 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 84630 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 61.0 nM | PMID7988476 | BindingDB |
Ki | 1000.0 nM | PMID8100350 | BindingDB |
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