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Name | Hydroxycarboxylic acid receptor 2 |
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Species | Homo sapiens (Human) |
Gene | HCAR2 |
Synonym | G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 [ Show all ] |
Disease | Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis [ Show all ] |
Length | 363 |
Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP |
UniProt | Q8TDS4 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDS4 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDS4. |
BioLiP | N/A |
Therapeutic Target Database | T00864 |
ChEMBL | CHEMBL3785 |
IUPHAR | 312 |
DrugBank | BE0000635 |
Name | CHEMBL237036 |
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Molecular formula | C16H14N4O4S |
IUPAC name | 2-[3-[2-(4-hydroxypyrazol-1-yl)-1,3-thiazol-5-yl]propanoylamino]benzoic acid |
Molecular weight | 358.372 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 2.1 |
Synonyms | BDBM23529 2-{3-[2-(4-hydroxy-1H-pyrazol-1-yl)-1,3-thiazol-5-yl]propanamido}benzoic acid Biaryl Anthranilide Analogue, 2k |
Inchi Key | CBQCLKNVINQXIV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H14N4O4S/c21-10-7-18-20(9-10)16-17-8-11(25-16)5-6-14(22)19-13-4-2-1-3-12(13)15(23)24/h1-4,7-9,21H,5-6H2,(H,19,22)(H,23,24) |
PubChem CID | 24741312 |
ChEMBL | CHEMBL237036 |
IUPHAR | N/A |
BindingDB | 23529 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 240.0 nM | PMID17994679 | BindingDB,ChEMBL |
Fold change | 500.0 - | PMID17994679 | ChEMBL |
IC50 | 20.0 nM | PMID17994679 | BindingDB,ChEMBL |
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