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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	1-Oleoyl Lysophosphatidic Acid
Molecular formula	C21H41O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	Epitope ID:158640 LPA(18:1/0:0) Lysophosphatidic acid(18:1/0:0) NKP ZINC8860530 1-O-oleyl-sn-glycerol 3-phosphate 1-oleyl-sn-glycerol 3-phosphate 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- HMS3650F05 LysoPA(18:1(9Z)/0:0) MolPort-009-019-282 SCHEMBL1560791 (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate 1-Oleoyl-L-.alpha.-lysophosphatidic acid 1293AH BSPBio_001406 LPA 18:1 lysophosphatidic acid NCGC00161386-02 UNII-PG6M3969SG component WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid 1-oleoylglycerol 3-phosphate 65528-98-5 HMS1791G08 LPA(18:1n9/0:0) Lysophosphatidic acid(18:1n9/0:0) PA(18:1(9Z)/0:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate 1-oleylglycerol 3-phosphate AC1NSKBQ C21H41O7P IDI1_033876 LysoPA(18:1) Monooleylphosphatidic acid SR-01000946335 (R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-propyl ester 1-Oleoyl-sn-glycero-3-phosphate 18:1 LPA CHEMBL117021 LPA(18:1(9Z)/0:0) Lysophosphatidic acid(18:1) NCGC00161386-03 WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-oleoyl-sn-glycerol 3-phosphate 1-oleyl-2-lyso-sn-glycerol 3-phosphatidic acid 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester HMS1989G08 LPA(18:1w9/0:0) Lysophosphatidic acid(18:1w9/0:0) PA(18:1/0:0) (2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate 1-oleoyl-2-lyso-sn-glycerol 3-phosphatidic acid 1-Oleyllysophosphatidic acid BDBM50148348 CHEBI:62837 LMGP10050008 LysoPA(18:1w9/0:0) NCGC00161386-01 SR-01000946335-1 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate 1-Oleoyl-sn-glycerol 3-phosphate [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
PubChem CID	5311263
ChEMBL	CHEMBL117021
IUPHAR	N/A
BindingDB	50148348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	17.0 nM	PMID15177455	BindingDB,ChEMBL
EC50	17.78 nM	PMID23395664	ChEMBL
EC50	18.0 nM	PMID23395664	BindingDB,ChEMBL
EC50	31.0 nM	PMID20056548	BindingDB,ChEMBL
EC50	350.0 nM	PMID25100502	BindingDB,ChEMBL
Emax	100.0 %	PMID15177455	ChEMBL
Intrinsic activity	1.0 -	PMID23395664	ChEMBL

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