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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL2391448
Molecular formula	C13H13BrN4O2
IUPAC name	2-(5-amino-3-methyl-6-oxopyridazin-1-yl)-N-(4-bromophenyl)acetamide
Molecular weight	337.177
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.9
Synonyms	BDBM50435895
Inchi Key	WPYRTEPZXMIHCR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H13BrN4O2/c1-8-6-11(15)13(20)18(17-8)7-12(19)16-10-4-2-9(14)3-5-10/h2-6H,7,15H2,1H3,(H,16,19)
PubChem CID	71698442
ChEMBL	CHEMBL2391448
IUPHAR	N/A
BindingDB	50435895
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	8100.0 nM	PMID23685570	ChEMBL
Efficacy	115.0 %	PMID23685570	ChEMBL

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