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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd4
Synonym	D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P30729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3361
IUPHAR	217
DrugBank	N/A

Ligand

Name	CHEMBL219179
Molecular formula	C17H19N5O
IUPAC name	6-[4-(1H-benzimidazol-2-ylmethyl)piperazin-1-yl]pyridin-3-ol
Molecular weight	309.373
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.9
Synonyms	6-[4-(1H-benzimidazol-2-ylmethyl)piperazin-1-yl]pyridin-3-ol LS-193223 BDBM50200029 6-[4-(1H-Benzoimidazole-2-ylmethyl)piperazino]-3-pyridinol SCHEMBL4809015 CBDXXUZXRDBOGH-UHFFFAOYSA-N 6-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)pyridin-3-ol D0B0UZ A-425444 [ Show all ]
Inchi Key	CBDXXUZXRDBOGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N5O/c23-13-5-6-17(18-11-13)22-9-7-21(8-10-22)12-16-19-14-3-1-2-4-15(14)20-16/h1-6,11,23H,7-10,12H2,(H,19,20)
PubChem CID	9861462
ChEMBL	CHEMBL219179
IUPHAR	N/A
BindingDB	50200029
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13.7 nM	PMID17149874	ChEMBL
EC50	14.0 nM	PMID17149874	BindingDB
Efficacy	66.0 %	PMID17149874	ChEMBL

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