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GPCR

NameB2 bradykinin receptor
SpeciesCavia porcellus (Guinea pig)
GeneBDKRB2
SynonymB2R
BK-2 receptor
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
UniProtO70526
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4111
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL556176
Molecular formulaC20H20BrCl2N5O3
IUPAC nameN-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichlorophenyl]-N-methyl-2-(methylcarbamoylamino)acetamide
Molecular weight529.216
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.4
SynonymsSCHEMBL8564948
BDBM50062899
N-Methyl-N-[2,4-dichloro-3-[(2-methyl-3-bromoimidazo[1,2-a]pyridin-8-yl)oxymethyl]phenyl]-2-(3-methylureido)acetamide
CHEMBL1196218
N-[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-2-(3-methyl-ureido)-acetamide; hydrochloride
Inchi KeyCBBTUOINAJEZOJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H20BrCl2N5O3/c1-11-18(21)28-8-4-5-15(19(28)26-11)31-10-12-13(22)6-7-14(17(12)23)27(3)16(29)9-25-20(30)24-2/h4-8H,9-10H2,1-3H3,(H2,24,25,30)
PubChem CID10792291
ChEMBLN/A
IUPHARN/A
BindingDB50062899
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC5046.0 nMPMID9484506BindingDB

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