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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Homo sapiens (Human)
Gene	CHRM3
Synonym	cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 M3 receptor M3R [ Show all ]
Disease	Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease Glaucoma Diagnosing bronchial hyperreactivity Chronic obstructive pulmonary disease Seborrhea Sjogren's syndrome Spasms; Pain Unspecified Alzheimer disease Obstructive lung diseases [ Show all ]
Length	590
Amino acid sequence	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
UniProt	P20309
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T67684
ChEMBL	CHEMBL245
IUPHAR	15
DrugBank	BE0000045

Ligand

Name	Oxotremorine M
Molecular formula	C11H19N2O+
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium
Molecular weight	195.286
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	-0.1
Synonyms	L000458 NCGC00015758-03 PDSP1_000571 [3H]oxotremorine-M CCG-205035 GTPL303 KBio1_000379 LS-176344 NCGC00024979-02 Spectrum_001982 KBio2_007675 NCGC00015758-01 trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium BDBM50005677 D0G4CG Lopac-O-100 NCGC00015758-04 PDSP2_000569 CHEBI:38322 GTPL8595 KBio2_002539 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium NINDS_000379 Tocris-1067 AC1L1ILG CHEMBL44674 KBioSS_002548 NCGC00015758-02 oxotremorine-M ZINC1547932 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)- C11H19N2O DivK1c_000379 Lopac0_000954 NCGC00024979-01 SCHEMBL4542695 63939-65-1 CHEMBL23957 IDI1_000379 KBio2_005107 N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium OXO-M Trimethyl-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-ammonium; iodide AC1Q6FK0 D02WTM [ Show all ]
Inchi Key	CANZROMYQDHYHR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
PubChem CID	4629
ChEMBL	CHEMBL44674
IUPHAR	303, 8595
BindingDB	50005677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1800.0 nM	PMID20716489	BindingDB
Ki	7943.28 nM	PMID9224827	IUPHAR

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