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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL1080938
Molecular formulaC26H24N4O2
IUPAC name1H-indol-6-yl-[(2S)-2-methyl-4-(6-phenylpyridine-3-carbonyl)piperazin-1-yl]methanone
Molecular weight424.504
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.5
SynonymsBDBM50312788
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(6-phenylpyridin-3-yl)methanone
Inchi KeyWFMTXSXQVGYGHC-SFHVURJKSA-N
Inchi IDInChI=1S/C26H24N4O2/c1-18-17-29(25(31)22-9-10-23(28-16-22)19-5-3-2-4-6-19)13-14-30(18)26(32)21-8-7-20-11-12-27-24(20)15-21/h2-12,15-16,18,27H,13-14,17H2,1H3/t18-/m0/s1
PubChem CID46880726
ChEMBLCHEMBL1080938
IUPHARN/A
BindingDB50312788
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity19.0 %PMID20137933ChEMBL

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