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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL55460
Molecular formula	C20H27Cl2N3O2
IUPAC name	8-[2-[2-(2,5-dichloroanilino)ethyl-methylamino]ethyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	412.355
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.2
Synonyms	8-(2-{[2-(2,5-Dichloro-phenylamino)-ethyl]-methyl-amino}-ethyl)-8-aza-spiro[4.5]decane-7,9-dione BDBM50143710
Inchi Key	CAFBNEJZNQABOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H27Cl2N3O2/c1-24(9-8-23-17-12-15(21)4-5-16(17)22)10-11-25-18(26)13-20(14-19(25)27)6-2-3-7-20/h4-5,12,23H,2-3,6-11,13-14H2,1H3
PubChem CID	11350440
ChEMBL	CHEMBL55460
IUPHAR	N/A
BindingDB	50143710
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	673.67 nM	PMID15055991	BindingDB,ChEMBL

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