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Name | Thromboxane A2 receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Tbxa2r |
Synonym | Prostanoid TP receptor TP receptor TXA2-R |
Disease | N/A for non-human GPCRs |
Length | 341 |
Amino acid sequence | MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP |
UniProt | P30987 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1795181 |
IUPHAR | 346 |
DrugBank | N/A |
Name | CHEMBL2315054 |
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Molecular formula | C20H15Cl2FN2O2 |
IUPAC name | 6-[[5-chloro-2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]methyl]pyridine-2-carboxamide |
Molecular weight | 405.25 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.8 |
Synonyms | BDBM50424385 SCHEMBL2952676 WCTJTYALDQBUBV-UHFFFAOYSA-N 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)-methyl]-2-pyridinecarboxamide |
Inchi Key | WCTJTYALDQBUBV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H15Cl2FN2O2/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(25-16)20(24)26/h1-8,10H,9,11H2,(H2,24,26) |
PubChem CID | 24753314 |
ChEMBL | CHEMBL2315054 |
IUPHAR | N/A |
BindingDB | 50424385 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <1000.0 nM | PMID23218714 | ChEMBL |
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