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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL161427
Molecular formula	C29H37NO4
IUPAC name	(Z)-6-[(1R,2S,5S)-2-[(4-phenylphenyl)methoxy]-5-piperidin-1-ylcyclopentyl]oxyhex-4-enoic acid
Molecular weight	463.618
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BDBM50391278 SCHEMBL10555298
Inchi Key	BZYFYLPNTYTHJE-KPZIQFQPSA-N
Inchi ID	InChI=1S/C29H37NO4/c31-28(32)12-6-2-9-21-33-29-26(30-19-7-3-8-20-30)17-18-27(29)34-22-23-13-15-25(16-14-23)24-10-4-1-5-11-24/h1-2,4-5,9-11,13-16,26-27,29H,3,6-8,12,17-22H2,(H,31,32)/b9-2-/t26-,27-,29+/m0/s1
PubChem CID	13560651
ChEMBL	CHEMBL161427
IUPHAR	N/A
BindingDB	50391278
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	31.62 nM	Bioorg. Med. Chem. Lett., (1991) 1:12:689	ChEMBL
Kd	50.0 nM	N/A	BindingDB
Kd	50.12 nM	Bioorg. Med. Chem. Lett., (1991) 1:12:689	ChEMBL
Kd	794.0 nM	N/A	BindingDB
Kd	794.33 nM	N/A	BindingDB

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