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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL125078
Molecular formulaC36H61NO5S2
IUPAC name4-methylbenzenesulfonate;3-[7-[(4-tetradecyloxolan-2-yl)methoxy]heptyl]-1,3-thiazol-3-ium
Molecular weight652.006
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogPNone
SynonymsSCHEMBL9673470
Inchi KeyBZONEUFPEIYDEH-UHFFFAOYSA-M
Inchi IDInChI=1S/C29H54NO2S.C7H8O3S/c1-2-3-4-5-6-7-8-9-10-11-13-16-19-28-24-29(32-25-28)26-31-22-18-15-12-14-17-20-30-21-23-33-27-30;1-6-2-4-7(5-3-6)11(8,9)10/h21,23,27-29H,2-20,22,24-26H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
PubChem CID14785880
ChEMBLCHEMBL125078
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50830.0 nMPMID1992139ChEMBL

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