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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	CHEMBL1672734
Molecular formula	C12H10F2N2O3
IUPAC name	5-cyclobutyl-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Molecular weight	268.22
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.3
Synonyms	BDBM50337001 5-cyclobutyl-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Inchi Key	BZLHDLYMTJNPCY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H10F2N2O3/c13-9(14)10-15-11(18)8-6(5-2-1-3-5)4-7(17)19-12(8)16-10/h4-5,9H,1-3H2,(H,15,16,18)
PubChem CID	53317490
ChEMBL	CHEMBL1672734
IUPHAR	N/A
BindingDB	50337001
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID24900295	BindingDB,ChEMBL

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