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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL385957
Molecular formula	C25H22ClN3O
IUPAC name	N-(4-amino-2-propylquinolin-6-yl)-4-(4-chlorophenyl)benzamide
Molecular weight	415.921
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.8
Synonyms	SCHEMBL6202988 BDBM50193606 N-(4-amino-2-propylquinolin-6-yl)-4''-chlorobiphenyl-4-carboxamide
Inchi Key	BZLBLJIDXKUVIY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H22ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h4-15H,2-3H2,1H3,(H2,27,28)(H,29,30)
PubChem CID	44417832
ChEMBL	CHEMBL385957
IUPHAR	N/A
BindingDB	50193606
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	75.0 nM	PMID16919453	BindingDB,ChEMBL
IC50	0.7 nM	PMID16919453	BindingDB
IC50	0.7 nM	PMID16919453	ChEMBL

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