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GPCR

NameType-2 angiotensin II receptor
SpeciesHomo sapiens (Human)
GeneAGTR2
SynonymAT2
MRX88
Agtr2
angiotensin II receptor
angiotensin II receptor, type 2
[ Show all ]
DiseasePostherpetic neuralgia
Hypertension
Length363
Amino acid sequenceMKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
UniProtP50052
Protein Data Bank5xjm, 5unh, 5ung, 5unf
GPCR-HGmod modelP50052
3D structure modelThis structure is from PDB ID 5xjm.
BioLiPBL0419199, BL0375199,BL0375200, BL0375198, BL0375196,BL0375197
Therapeutic Target DatabaseT09909
ChEMBLCHEMBL4607
IUPHAR35
DrugBankBE0003426

Ligand

NameCHEMBL2435834
Molecular formulaC33H31N3O3
IUPAC name2-[4-[[4-methyl-6-[(4-methylphenyl)carbamoyl]-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
Molecular weight517.629
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP6.9
SynonymsN/A
Inchi KeyBZHLUYSOYJBCMN-UHFFFAOYSA-N
Inchi IDInChI=1S/C33H31N3O3/c1-4-7-30-35-31-22(3)18-25(32(37)34-26-16-10-21(2)11-17-26)19-29(31)36(30)20-23-12-14-24(15-13-23)27-8-5-6-9-28(27)33(38)39/h5-6,8-19H,4,7,20H2,1-3H3,(H,34,37)(H,38,39)
PubChem CID73357018
ChEMBLCHEMBL2435834
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5061.0 nMPMID24007859ChEMBL

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