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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesRattus norvegicus (Rat)
GenePtger2
SynonymEP2 receptor
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProtQ62928
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4909
IUPHAR341
DrugBankN/A

Ligand

NameCHEMBL208399
Molecular formulaC27H35NO4
IUPAC name7-[(2S)-2-[(3R)-3-hydroxy-4-(3-phenylphenyl)butyl]-5-oxopyrrolidin-1-yl]heptanoic acid
Molecular weight437.58
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.6
Synonyms7-[(S)-2-((R)-4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid
BDBM50181273
Inchi KeyVPOFGSXFQMDGLT-LOSJGSFVSA-N
Inchi IDInChI=1S/C27H35NO4/c29-25(20-21-9-8-12-23(19-21)22-10-4-3-5-11-22)16-14-24-15-17-26(30)28(24)18-7-2-1-6-13-27(31)32/h3-5,8-12,19,24-25,29H,1-2,6-7,13-18,20H2,(H,31,32)/t24-,25+/m0/s1
PubChem CID44409712
ChEMBLCHEMBL208399
IUPHARN/A
BindingDB50181273
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<3200.0 nMPMID16442794BindingDB,ChEMBL

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