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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesHomo sapiens (Human)
GeneCHRM2
Synonymcholinergic receptor
AChR M2
M2 muscarinic acetylcholine receptor
M2 receptor
Chrm-2
[ Show all ]
DiseaseUrinary incontinence
Heart failure
Nausea; Addiction
Parkinson's disease
Peptic ulcer
[ Show all ]
Length466
Amino acid sequenceMNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP08172
Protein Data Bank5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod modelP08172
3D structure modelThis structure is from PDB ID 5zkc.
BioLiPBL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target DatabaseT46185
ChEMBLCHEMBL211
IUPHAR14
DrugBankBE0000560

Ligand

NameCarbamylcholine
Molecular formulaC6H15N2O2+
IUPAC name2-carbamoyloxyethyl(trimethyl)azanium
Molecular weight147.198
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP-0.4
SynonymsCarbachol USP27
Carbastat (TN)
DTXSID0048397
KBio1_000725
Lopac-C-4382
[ Show all ]
Inchi KeyVPJXQGSRWJZDOB-UHFFFAOYSA-O
Inchi IDInChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1
PubChem CID2551
ChEMBLCHEMBL965
IUPHAR298
BindingDB50004656
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5074.0 nMPMID7783150BindingDB
EC50110.0 nMPMID7990109BindingDB
EC50700.0 nMPMID9873644, PMID10354408BindingDB
EC5061000.0 nMPMID9651157BindingDB
IC503.8 nMPMID9873472BindingDB
IC5013.0 nMPMID13678406BindingDB
IC50130.0 nMPMID9622546BindingDB
IC501400.0 nMPMID9435896BindingDB
IC503100.0 nMPMID9622546BindingDB
IC503460.0 nMN/ABindingDB
IC50119000.0 nMPMID9651157BindingDB
Ki<10000.0 nMPMID12235229BindingDB
Ki20.0 nMPMID9622546, PMID10891110BindingDB
Ki38.0 nMPMID10891110BindingDB
Ki331.13 nMPMID8968358BindingDB
Ki1230.0 nMPMID24980056, PMID18077164BindingDB
Ki1230.27 nMPMID19896386, PMID18543900BindingDB
Ki1300.0 nMPMID12747793BindingDB
Ki1820.0 nMPMID9454790BindingDB
Ki1995.26 - 63095.7 nMPMID12235229, PMID9224827, PMID9454790IUPHAR

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