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Name | Muscarinic acetylcholine receptor M2 |
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Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | Carbamylcholine |
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Molecular formula | C6H15N2O2+ |
IUPAC name | 2-carbamoyloxyethyl(trimethyl)azanium |
Molecular weight | 147.198 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | -0.4 |
Synonyms | Carbachol USP27 Carbastat (TN) DTXSID0048397 KBio1_000725 Lopac-C-4382 [ Show all ] |
Inchi Key | VPJXQGSRWJZDOB-UHFFFAOYSA-O |
Inchi ID | InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1 |
PubChem CID | 2551 |
ChEMBL | CHEMBL965 |
IUPHAR | 298 |
BindingDB | 50004656 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 74.0 nM | PMID7783150 | BindingDB |
EC50 | 110.0 nM | PMID7990109 | BindingDB |
EC50 | 700.0 nM | PMID9873644, PMID10354408 | BindingDB |
EC50 | 61000.0 nM | PMID9651157 | BindingDB |
IC50 | 3.8 nM | PMID9873472 | BindingDB |
IC50 | 13.0 nM | PMID13678406 | BindingDB |
IC50 | 130.0 nM | PMID9622546 | BindingDB |
IC50 | 1400.0 nM | PMID9435896 | BindingDB |
IC50 | 3100.0 nM | PMID9622546 | BindingDB |
IC50 | 3460.0 nM | N/A | BindingDB |
IC50 | 119000.0 nM | PMID9651157 | BindingDB |
Ki | <10000.0 nM | PMID12235229 | BindingDB |
Ki | 20.0 nM | PMID9622546, PMID10891110 | BindingDB |
Ki | 38.0 nM | PMID10891110 | BindingDB |
Ki | 331.13 nM | PMID8968358 | BindingDB |
Ki | 1230.0 nM | PMID24980056, PMID18077164 | BindingDB |
Ki | 1230.27 nM | PMID19896386, PMID18543900 | BindingDB |
Ki | 1300.0 nM | PMID12747793 | BindingDB |
Ki | 1820.0 nM | PMID9454790 | BindingDB |
Ki | 1995.26 - 63095.7 nM | PMID12235229, PMID9224827, PMID9454790 | IUPHAR |
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