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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1E
Species	Homo sapiens (Human)
Gene	HTR1E
Synonym	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 5-HT1E_alpha 5-ht1e receptor 5-HT1E 5-HT-1E S31 Serotonin receptor 1E [ Show all ]
Disease	N/A
Length	365
Amino acid sequence	MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
UniProt	P28566
Protein Data Bank	N/A
GPCR-HGmod model	P28566
3D structure model	This predicted structure model is from GPCR-EXP P28566.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2182
IUPHAR	4
DrugBank	BE0000476

Ligand

Name	1-(1-Naphthyl)piperazine
Molecular formula	C14H16N2
IUPAC name	1-naphthalen-1-ylpiperazine
Molecular weight	212.296
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.6
Synonyms	NCGC00015905-04 SCHEMBL240244 1-naphthalen-1-yl-piperazine, AldrichCPR Biomol-NT_000100 D03TDN N-(1- naphthyl)piperazine N-(1-naphthyl)piperazine Oprea1_621306 1-(1-Naphthyl)piperazine HCl_x000D_ AC1Q1INU CCG-205255 L001113 NCGC00015905-02 Piperazine, 1-(1-naphthalenyl)- 1-(naphthalene-1-yl)piperazine 4-(naphth-1-yl)piperazine BC4157455 CHEMBL277120 MCULE-4447428643 N-(1-naphthyl) piperazine NCGC00162360-01 VNICFCQJUVFULD-UHFFFAOYSA-N 1-naphthalen-1-ylpiperazine 57536-86-4 BPBio1_001387 D04YOT Naphthylpiperazine PDSP1_000930 1-(naphth-1-yl)piperazine 4-(1-naphthyl) piperazine AKOS003591178 CHEBI:108599 Lopac-S-003 NCGC00015905-03 Piperazine,1-(1-naphthalenyl)- 1-Naphthalen-1-yl-piperazine 4-Naphthalen-1-yl-piperazin-1-ium BDBM50007407 CTK5A7019 MolPort-002-344-189 N-(1-naphthyl)-piperazine NCGC00162360-02 ZINC2516045 1-Naphthylpiperazine AC1L1B9K BRD-K05977380-001-01-7 GTPL3 NCGC00015905-01 PDSP2_000916 1-(naphthalen-1-yl)piperazine 4-(1-naphthyl)piperazine AT-057/41429159 Lopac0_001181 [ Show all ]
Inchi Key	VNICFCQJUVFULD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PubChem CID	1342
ChEMBL	CHEMBL277120
IUPHAR	3
BindingDB	50007407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	100.0 - 199.526 nM	PMID8863519, PMID8380639, PMID14744596	IUPHAR
Ki	207.0 nM	PMID1513320	PDSP
Ki	208.92 nM	PMID7984267	PDSP,BindingDB

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