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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	1-(1-Naphthyl)piperazine
Molecular formula	C14H16N2
IUPAC name	1-naphthalen-1-ylpiperazine
Molecular weight	212.296
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.6
Synonyms	NCGC00162360-02 ZINC2516045 1-Naphthylpiperazine AC1L1B9K BRD-K05977380-001-01-7 GTPL3 N-(1-naphthyl)-piperazine NCGC00015905-01 PDSP2_000916 1-(naphthalen-1-yl)piperazine 4-(1-naphthyl)piperazine AT-057/41429159 Lopac0_001181 NCGC00015905-04 SCHEMBL240244 1-naphthalen-1-yl-piperazine, AldrichCPR Biomol-NT_000100 D03TDN N-(1- naphthyl)piperazine Oprea1_621306 1-(1-Naphthyl)piperazine HCl_x000D_ AC1Q1INU CCG-205255 L001113 N-(1-naphthyl)piperazine NCGC00015905-02 Piperazine, 1-(1-naphthalenyl)- 1-(naphthalene-1-yl)piperazine 4-(naphth-1-yl)piperazine BC4157455 CHEMBL277120 MCULE-4447428643 NCGC00162360-01 VNICFCQJUVFULD-UHFFFAOYSA-N 1-naphthalen-1-ylpiperazine 57536-86-4 BPBio1_001387 D04YOT N-(1-naphthyl) piperazine PDSP1_000930 1-(naphth-1-yl)piperazine 4-(1-naphthyl) piperazine AKOS003591178 CHEBI:108599 Lopac-S-003 Naphthylpiperazine NCGC00015905-03 Piperazine,1-(1-naphthalenyl)- 1-Naphthalen-1-yl-piperazine 4-Naphthalen-1-yl-piperazin-1-ium BDBM50007407 CTK5A7019 MolPort-002-344-189 [ Show all ]
Inchi Key	VNICFCQJUVFULD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PubChem CID	1342
ChEMBL	CHEMBL277120
IUPHAR	3
BindingDB	50007407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.89 nM	PMID9459568	PDSP,BindingDB
Ki	1.0 - 3.98107 nM	PMID8078486, PMID9459568	IUPHAR
Ki	3.25 nM	PMID9459568	PDSP
Ki	3.72 nM	PMID8632342	PDSP,BindingDB
Ki	3.8 nM	PMID8078486	PDSP

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