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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	1-(1-Naphthyl)piperazine
Molecular formula	C14H16N2
IUPAC name	1-naphthalen-1-ylpiperazine
Molecular weight	212.296
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.6
Synonyms	1-Naphthalen-1-yl-piperazine 4-Naphthalen-1-yl-piperazin-1-ium BDBM50007407 CTK5A7019 MolPort-002-344-189 NCGC00015905-03 Piperazine,1-(1-naphthalenyl)- 1-Naphthylpiperazine AC1L1B9K BRD-K05977380-001-01-7 GTPL3 N-(1-naphthyl)-piperazine NCGC00162360-02 ZINC2516045 4-(1-naphthyl)piperazine AT-057/41429159 Lopac0_001181 NCGC00015905-01 PDSP2_000916 1-(naphthalen-1-yl)piperazine 1-naphthalen-1-yl-piperazine, AldrichCPR Biomol-NT_000100 D03TDN N-(1- naphthyl)piperazine NCGC00015905-04 SCHEMBL240244 AC1Q1INU CCG-205255 L001113 N-(1-naphthyl)piperazine Oprea1_621306 1-(1-Naphthyl)piperazine HCl_x000D_ 1-(naphthalene-1-yl)piperazine 4-(naphth-1-yl)piperazine BC4157455 CHEMBL277120 MCULE-4447428643 NCGC00015905-02 Piperazine, 1-(1-naphthalenyl)- 1-naphthalen-1-ylpiperazine 57536-86-4 BPBio1_001387 D04YOT N-(1-naphthyl) piperazine NCGC00162360-01 VNICFCQJUVFULD-UHFFFAOYSA-N 4-(1-naphthyl) piperazine AKOS003591178 CHEBI:108599 Lopac-S-003 Naphthylpiperazine PDSP1_000930 1-(naphth-1-yl)piperazine [ Show all ]
Inchi Key	VNICFCQJUVFULD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PubChem CID	1342
ChEMBL	CHEMBL277120
IUPHAR	3
BindingDB	50007407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	100.0 nM	PMID15745826	BindingDB,ChEMBL
Ki	104.0 nM	PMID8226867, PMID12825922	PDSP,BindingDB,ChEMBL
Ki	120.0 nM	PMID15745826	PDSP,BindingDB,ChEMBL

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