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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	1-(1-Naphthyl)piperazine
Molecular formula	C14H16N2
IUPAC name	1-naphthalen-1-ylpiperazine
Molecular weight	212.296
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.6
Synonyms	Biomol-NT_000100 D03TDN N-(1- naphthyl)piperazine NCGC00015905-04 SCHEMBL240244 1-naphthalen-1-yl-piperazine, AldrichCPR AC1Q1INU CCG-205255 L001113 N-(1-naphthyl)piperazine Oprea1_621306 1-(1-Naphthyl)piperazine HCl_x000D_ 4-(naphth-1-yl)piperazine BC4157455 CHEMBL277120 MCULE-4447428643 NCGC00015905-02 Piperazine, 1-(1-naphthalenyl)- 1-(naphthalene-1-yl)piperazine 57536-86-4 BPBio1_001387 D04YOT N-(1-naphthyl) piperazine NCGC00162360-01 VNICFCQJUVFULD-UHFFFAOYSA-N 1-naphthalen-1-ylpiperazine AKOS003591178 CHEBI:108599 Lopac-S-003 Naphthylpiperazine PDSP1_000930 1-(naphth-1-yl)piperazine 4-(1-naphthyl) piperazine 4-Naphthalen-1-yl-piperazin-1-ium BDBM50007407 CTK5A7019 MolPort-002-344-189 NCGC00015905-03 Piperazine,1-(1-naphthalenyl)- 1-Naphthalen-1-yl-piperazine AC1L1B9K BRD-K05977380-001-01-7 GTPL3 N-(1-naphthyl)-piperazine NCGC00162360-02 ZINC2516045 1-Naphthylpiperazine 4-(1-naphthyl)piperazine AT-057/41429159 Lopac0_001181 NCGC00015905-01 PDSP2_000916 1-(naphthalen-1-yl)piperazine [ Show all ]
Inchi Key	VNICFCQJUVFULD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PubChem CID	1342
ChEMBL	CHEMBL277120
IUPHAR	3
BindingDB	50007407
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6.18 nM	PMID9871775	ChEMBL
Ki	6.2 nM	PMID9871775, PMID9397179	PDSP,BindingDB,ChEMBL
Ki	6.30957 - 7.94328 nM	PMID9397179, PMID1565658	IUPHAR
Ki	7.41 nM	PMID7984267	PDSP,BindingDB
Ki	12.0 nM	PMID1565658	PDSP,BindingDB

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