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GPCR

Name	Alpha-1A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1A
Synonym	alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c adrenergic receptor, alpha 1a alpha 1A-adrenoceptor alpha 1A-adrenoreceptor alpha1c alpha 1C-adrenergic receptor alpha-1A adrenergic receptor Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c alpha1A-adrenoceptor [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma Hypertension Major depressive disorder Pain Post-traumatic stress disorder Prostate cancer; Benign prostatic hyperplasia Prostate disease Prostate hyperplasia Stress urinary incontinence Unspecified [ Show all ]
Length	466
Amino acid sequence	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
UniProt	P35348
Protein Data Bank	N/A
GPCR-HGmod model	P35348
3D structure model	This predicted structure model is from GPCR-EXP P35348.
BioLiP	N/A
Therapeutic Target Database	T92609
ChEMBL	CHEMBL229
IUPHAR	22
DrugBank	BE0000501

Ligand

Name	Tetryzoline
Molecular formula	C13H16N2
IUPAC name	2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.8
Synonyms	BSPBio_000855 CHEBI:28674 DivK1c_000854 KB-61571 Lopac0_001137 NCGC00016018-07 (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride Spectrum5_001022 522-48-5 (mono-hydrochloride) Tetrizolina AKOS017258508 Tetryzolinum [INN-Latin] Visine C-23911 cid_10648 FT-0690208 KBio2_004084 MCULE-1878887684 Opticlear 1H-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride SPBio_001459 2-tetralin-1-yl-2-imidazoline;hydrochloride STL163582 tetryzolina BDBM96559 CC-34953 I14-11411 KBioGR_001561 NCGC00016018-03 Prestwick2_000698 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline Spectrum3_000582 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthyl)-1H-imidazole tetrahydrozoline, (+-)-isomer AC1L1KBE Tetryzoline [INN:BAN] BRD-A28856712-003-15-3 BSPBio_002024 DTXSID1047861 KBio1_000854 LS-176618 NCGC00089820-02 084T220 SBI-0051104.P004 2-(1,2,3,4-tetrahydronaphthyl)-2-imidazoline Spectrum_001036 67731-52-6 Tetrizolina [INN-Spanish] ALBB-023224 Tyzanol ZX-AN021738 C07912 D05IHU HMS3561J13 KBio2_006652 MolPort-001-684-719 Prestwick0_000698 1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- SPBio_002776 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole teetryzoline AB00053551_11 BPBio1_000941 BRN 0011442 CCG-202845 DB06764 IDI1_000854 KBioSS_001516 NCGC00016018-04 Prestwick3_000698 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole Spectrum4_000871 5-23-07-00394 (Beilstein Handbook Reference) Tetrahydrozolinum AKOS003659212 Tetryzolinum BYJAVTDNIXVSPW-UHFFFAOYSA-N CHEMBL1266 EINECS 201-522-3 KBio2_001516 LS-79680 NINDS_000854 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- SCHEMBL34760 2-IMIDAZOLINE, 2-(1,2,3,4-TETRAHYDRO-1-NAPHTHYL)- ST024759 84-22-0 Tetryzolin AN-42275 Tyzine Caltheon (TN) D08578 HSDB 7471 KBio3_001524 MRF-0000521 Prestwick1_000698 2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazole Spectrum2_001330 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole tetrahydrozoline AB00053551_12 Tetryzoline (INN) BRD-A28856712-003-05-4 [ Show all ]
Inchi Key	BYJAVTDNIXVSPW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)
PubChem CID	5419
ChEMBL	CHEMBL1266
IUPHAR	N/A
BindingDB	96559
DrugBank	DB06764
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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