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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	5-Fluoronicotinic acid
Molecular formula	C6H4FNO2
IUPAC name	5-fluoropyridine-3-carboxylic acid
Molecular weight	141.101
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	ABBYPHARMA AP-15-5209 AKOS005137907 BCP24542 CTK1D6970 I02-1840 MCULE-7456596815 R622 STL553784 3-Pyridinecarboxylic acid, 5-fluoro- 5-fluoropyridine-3-carboxylic acid AC1L3QD5 ANW-29343 BXZSBDDOYIWMGC-UHFFFAOYSA-N F0738 KB-43305 Nicotinic acid, 5-fluoro- SBB053038 TL8002924 4CH-006274 5-Fluoro-nicotinic acid AB0018232 AJ-34459 BBL100212 CHEMBL397783 FT-0081895 LF10514 PubChem10942 ST2412024 3-Fluoro-5-carboxypyridine ZINC2244270 5-Fluoronicotinic Acid ,97% ABBYPHARMA AP-15-5212 AM20051156 BDBM50216521 DB-029153 J-517558 MFCD01318537 RP01274 SY005275 402-66-4 5-fluoro nicotinic acid ACMC-209jch AS04871 CF-235 F1905-7160 KS-000008DA PB23226 SC-26814 TRA0051909 5-fluoroisonicotinic acid AB1000411 AK-25931 BC228161 CS-W016443 FT-0600683 LS-130942 QC-1770 ST50949605 3-FLUORO-5-PYRIDINECARBOXYLIC ACID 5-Fluoronicotinicacid AC-1806 AN-14604 BR-25931 DTXSID60193200 Jsp006965 MolPort-000-003-905 RTC-060770 TC-060770 402F664 5-Fluoro-3-pyridinecarboxylic acid A6737 ACN-S004161 B-3137 F67416 KSC236S7B PS-9027 SCHEMBL430582 Z1741967935 [ Show all ]
Inchi Key	BXZSBDDOYIWMGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H4FNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)
PubChem CID	120232
ChEMBL	CHEMBL397783
IUPHAR	N/A
BindingDB	50216521
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5300.0 nM	PMID17588745	BindingDB,ChEMBL

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