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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL369482
Molecular formula	C46H56N12O6
IUPAC name	(2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-imidazol-1-ylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Molecular weight	873.032
Hydrogen bond acceptor	9
Hydrogen bond donor	10
XlogP	1.5
Synonyms	N/A
Inchi Key	VHYVGEMUOBSMJT-QPAOXRNZSA-N
Inchi ID	InChI=1S/C46H56N12O6/c1-28(53-44(62)39(22-30-24-51-35-15-7-5-13-32(30)35)56-43(61)34(48)26-58-20-19-50-27-58)42(60)55-40(23-31-25-52-36-16-8-6-14-33(31)36)46(64)57-38(21-29-11-3-2-4-12-29)45(63)54-37(41(49)59)17-9-10-18-47/h2-8,11-16,19-20,24-25,27-28,34,37-40,51-52H,9-10,17-18,21-23,26,47-48H2,1H3,(H2,49,59)(H,53,62)(H,54,63)(H,55,60)(H,56,61)(H,57,64)/t28-,34-,37-,38+,39+,40+/m0/s1
PubChem CID	44387246
ChEMBL	CHEMBL369482
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
ED50	10.0 nM	Bioorg. Med. Chem. Lett., (1994) 4:9:1117	ChEMBL

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