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Name | Platelet-activating factor receptor |
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Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL293773 |
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Molecular formula | C31H38O10S2 |
IUPAC name | (5S)-2-[4-[2-(benzenesulfonyl)ethoxy]-3-methoxy-5-propylsulfonylphenyl]-5-(3,4,5-trimethoxyphenyl)oxolane |
Molecular weight | 634.755 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 0 |
XlogP | 4.5 |
Synonyms | BDBM50280339 L-671284 (S)-2-[4-(2-Benzenesulfonyl-ethoxy)-3-methoxy-5-(propane-1-sulfonyl)-phenyl]-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan |
Inchi Key | BXWTUZMSCVMABI-SKCDSABHSA-N |
Inchi ID | InChI=1S/C31H38O10S2/c1-6-15-43(34,35)29-20-22(19-28(38-4)31(29)40-14-16-42(32,33)23-10-8-7-9-11-23)25-13-12-24(41-25)21-17-26(36-2)30(39-5)27(18-21)37-3/h7-11,17-20,24-25H,6,12-16H2,1-5H3/t24-,25?/m0/s1 |
PubChem CID | 44297792 |
ChEMBL | CHEMBL293773 |
IUPHAR | N/A |
BindingDB | 50280339 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.0 nM | , Bioorg. Med. Chem. Lett., (1992) 2:2:181 | BindingDB,ChEMBL |
Inhibition | 72.0 % | Bioorg. Med. Chem. Lett., (1992) 2:2:181 | ChEMBL |
Ki | 1.0 nM | , Bioorg. Med. Chem. Lett., (1992) 2:2:181 | BindingDB,ChEMBL |
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