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Name | Prostaglandin D2 receptor |
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Species | Homo sapiens (Human) |
Gene | PTGDR |
Synonym | PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like [ Show all ] |
Disease | Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis [ Show all ] |
Length | 359 |
Amino acid sequence | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL |
UniProt | Q13258 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13258 |
3D structure model | This predicted structure model is from GPCR-EXP Q13258. |
BioLiP | N/A |
Therapeutic Target Database | T68782 |
ChEMBL | CHEMBL4427 |
IUPHAR | 338 |
DrugBank | BE0000296 |
Name | CHEMBL309847 |
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Molecular formula | C24H35NO4S |
IUPAC name | (Z)-7-[(1S,2R,3R,4R)-3-[(4-tert-butylphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acid |
Molecular weight | 433.607 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 5.3 |
Synonyms | (+) 7-[3-(4-tert-Butyl-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid BDBM50128726 |
Inchi Key | BXWKTNRURSAYJZ-CIYNECQDSA-N |
Inchi ID | InChI=1S/C24H35NO4S/c1-24(2,3)19-12-14-20(15-13-19)30(28,29)25-23-18-11-10-17(16-18)21(23)8-6-4-5-7-9-22(26)27/h4,6,12-15,17-18,21,23,25H,5,7-11,16H2,1-3H3,(H,26,27)/b6-4-/t17-,18+,21+,23+/m0/s1 |
PubChem CID | 11826199 |
ChEMBL | CHEMBL309847 |
IUPHAR | N/A |
BindingDB | 50128726 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID12773047 | BindingDB,ChEMBL |
IC50 | 720.0 nM | PMID12773047 | BindingDB,ChEMBL |
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