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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	HARMINE
Molecular formula	C13H12N2O
IUPAC name	7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Molecular weight	212.252
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.6
Synonyms	Telepathien Yageine Garmin 1-Methyl-7-methoxy-.beta.-carboline HMS2090H04 4CN-1047 KBio1_001651 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, 9CI Leucoharmine AB00052850-08 NCGC00016435-01 AN-5374 NCGC00094869-01 BAS 00654992 Prestwick0_000613 BRD-K30984264-001-04-7 SDCCGMLS-0066733.P001 C13H12N2O Spectrum4_001004 CTK3J1336 ST069315 TL8003082 Harmin HRM 7-Methoxy-1-methyl-9H-beta-carboline KBio2_006744 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl- MEGxp0_001875 ACMC-209jws NCGC00016435-04 AS-13970 NCGC00094869-04 BIDD:GT0106 Prestwick3_000613 BRD-K30984264-003-06-8 SPBio_002765 CHEBI:28121 SR-05000001527 DB07919 VA10371 Harmine, 98% 442-51-3 (FREE BASE) InChI=1/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole KBioSS_001608 A826517 MolPort-000-745-604 AK111268 NCGC00016435-07 Banisterine Oprea1_596686 BPBio1_000602 SC-78608 BXNJHAXVSOCGBA-UHFFFAOYSA-N Spectrum2_000568 cid_5359389 SR-05000001527-5 EINECS 207-131-4 Telepathin Yajeine GTPL9352 1-Methyl-7-methoxy-beta -carboline HMS3561B11 4FHH5G48T7 KBio2_001608 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride LS-133548 AC1NQXSY NCGC00016435-02 ANW-30074 NCGC00094869-02 BDBM100152 Prestwick1_000613 BRD-K30984264-001-05-4 SMR001233259 CAS-343-27-1 Spectrum5_001914 D00OWF ST24045676 TR-017050 Harmin hydrochloride 3anr HY-N0737A 7-Methoxy-1-methyl-9H-beta-carboline # KBio3_001852 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl- MFCD00004958 ACon0_001194 NCGC00016435-05 AX8014622 NCGC00094869-05 BIDF1036 Q568 BRN 0178813 SpecPlus_000611 SR-05000001527-1 DivK1c_006707 Yagein HMS1921M06 442H513 KB-249995 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole KS-00000GV3 AB00052850 N-(sec-butyl)-6-(4-{[(5-chloro-2-thienyl)sulfonyl]amino}phenoxy)nicotinamide AKOS003673313 NCGC00016435-09 Banisterine monohydrate OR52246 BRD-K30984264-001-01-3 SCHEMBL292955 C06538 Spectrum3_000906 CS-5325 SR-05000001527-8 FT-0626860 Telepathine ZINC18847046 H-1200 1-Methyl-7-methoxy-beta-carboline HMS3650H03 5-23-12-00237 (Beilstein Handbook Reference) KBio2_004176 7-methoxy-1-methylbeta-carboline MCULE-9544425288 AC1Q4EU6 NCGC00016435-03 API0002888 NCGC00094869-03 BIDD:ER0478 Prestwick2_000613 BRD-K30984264-003-03-5 SPBio_000356 CCG-38734 Spectrum_001128 D0V4XE STK047386 UNII-4FHH5G48T7 442-51-3 I14-18972 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride KBioGR_001467 A1-03319 MLS002153910 ACon1_000061 NCGC00016435-06 Banisterin NCGC00094869-06 BP-30211 RTR-017050 BSPBio_000546 SPECTRUM1500867 CHEMBL269538 SR-05000001527-4 DTXSID30196066 [ Show all ]
Inchi Key	BXNJHAXVSOCGBA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
PubChem CID	5280953
ChEMBL	CHEMBL269538
IUPHAR	N/A
BindingDB	100152
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	810.0 nM	PMID14643338	BindingDB,ChEMBL

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