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GPCR

Name	Alpha-1D adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1D
Synonym	alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R ADRA1A ADRA1 Adra-1 alpha 1D-adrenoceptor alpha 1D-adrenoreceptor alpha1D-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-adrenergic receptor 1a Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Alpha-1A adrenergic receptor alpha1D-AR [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction Fecal incontinence Glaucoma Hypertension Pediatric cancer Peripheral vascular disease Prostate disease Prostate hyperplasia [ Show all ]
Length	572
Amino acid sequence	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProt	P25100
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T53381
ChEMBL	CHEMBL223
IUPHAR	24
DrugBank	BE0004863, BE0000715

Ligand

Name	terazosin
Molecular formula	C19H25N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
Molecular weight	387.44
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.4
Synonyms	GTPL7302 Hytracin MET029 NCGC00016026-04 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick1_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine STK567029 Terazosina AN-38972 Vasomet C07127 D08569 DB01162 HMS2232N21 KB-147102 MLS000069703 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine NCGC00016026-11 141269-45-6 REGID_for_CID_5401 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine Abbott 45975 Terazosine [INN-French] Blavin [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone CHEBI:9445 Fosfomic HMS3371E20 LS-110234 MolPort-001-684-489 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)- 590T647 SMR000058309 63590-64-7 Terazosin HCl AC1L1K9W Trazosin HCl BRD-A22256192-003-14-4 CPD000058309 H963 Hytrin Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)- (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone NCGC00016026-05 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine Prestwick2_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine Terazosabb A 45975 Terazosina [INN-Spanish] BBL010743 VCKUSRYTPJJLNI-UHFFFAOYSA-N C19H25N5O4 D0P9RF DTXSID3023639 HMS3259F04 L000692 MLS001201836 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine NCGC00025191-03 4097AH SAM002589982 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine Terazosin (INN) Abbott-45975 Terazosinum BPBio1_000840 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone FT-0630739 HY-B0371 MCULE-4030111564 NC00689 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick0_000751 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine SPBio_002701 70024-40-7 (mono-hydrochloride, dihydrate) Terazosin [INN:BAN] AKOS005266642 VA11839 BSPBio_000762 CS-2429 HMS2090P21 Hytrin (TN) MFCD00467965 NCGC00016026-08 141269-44-5 Prestwick3_000751 6,7-Dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine # Terazosabb (TN) A-45975 Terazosine BDBM50033111 Z1172269406 CCG-205212 Flumarc HMS3369P14 Lopac0_001138 MLS006011889 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine Opera_ID_1910 SCHEMBL6528 63074-08-8 (hydrochloride) terazosin a AC-11120 Terazosinum [INN-Latin] BRD-A22256192-003-03-7 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone CHEMBL611 [ Show all ]
Inchi Key	VCKUSRYTPJJLNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
PubChem CID	5401
ChEMBL	CHEMBL611
IUPHAR	7302
BindingDB	50033111
DrugBank	DB01162
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	17.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	0.66 nM	PMID11805207	BindingDB
Ki	0.660693 nM	PMID11805207	PDSP
Ki	0.85 nM	PMID9379432	BindingDB,ChEMBL
Ki	0.85 nM	PMID9379432	IUPHAR
Ki	2.0 nM	PMID9873563, PMID9548811	BindingDB,ChEMBL
Ki	3.467 nM	PMID9651170	ChEMBL
Ki	3.5 nM	PMID7658428, PMID10579840, PMID10579842	BindingDB,ChEMBL
Ki	3.7 nM	PMID7752182	BindingDB,ChEMBL
Ki	3.981 nM	PMID9135028	ChEMBL
Ki	8.363 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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