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GLASS

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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	terazosin
Molecular formula	C19H25N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
Molecular weight	387.44
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.4
Synonyms	Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)- 590T647 SMR000058309 63590-64-7 Terazosin HCl AC1L1K9W Trazosin HCl BRD-A22256192-003-14-4 CPD000058309 Fosfomic HMS3371E20 LS-110234 MolPort-001-684-489 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine Prestwick2_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine Terazosabb A 45975 Terazosina [INN-Spanish] BBL010743 VCKUSRYTPJJLNI-UHFFFAOYSA-N C19H25N5O4 D0P9RF H963 Hytrin Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)- (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone NCGC00016026-05 NCGC00025191-03 4097AH SAM002589982 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine Terazosin (INN) Abbott-45975 Terazosinum BPBio1_000840 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone DTXSID3023639 HMS3259F04 L000692 MLS001201836 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick0_000751 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine SPBio_002701 70024-40-7 (mono-hydrochloride, dihydrate) Terazosin [INN:BAN] AKOS005266642 VA11839 BSPBio_000762 CS-2429 FT-0630739 HY-B0371 MCULE-4030111564 NC00689 141269-44-5 Prestwick3_000751 6,7-Dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine # Terazosabb (TN) A-45975 Terazosine BDBM50033111 Z1172269406 CCG-205212 HMS2090P21 Hytrin (TN) MFCD00467965 NCGC00016026-08 Opera_ID_1910 SCHEMBL6528 63074-08-8 (hydrochloride) terazosin a AC-11120 Terazosinum [INN-Latin] BRD-A22256192-003-03-7 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone CHEMBL611 Flumarc HMS3369P14 Lopac0_001138 MLS006011889 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick1_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine STK567029 Terazosina AN-38972 Vasomet C07127 D08569 GTPL7302 Hytracin MET029 NCGC00016026-04 NCGC00016026-11 141269-45-6 REGID_for_CID_5401 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine Abbott 45975 Terazosine [INN-French] Blavin [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone CHEBI:9445 DB01162 HMS2232N21 KB-147102 MLS000069703 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine [ Show all ]
Inchi Key	VCKUSRYTPJJLNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
PubChem CID	5401
ChEMBL	CHEMBL611
IUPHAR	7302
BindingDB	50033111
DrugBank	DB01162
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	24.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Kb	19.0 nM	PMID9873563	ChEMBL
Kb	27.0 nM	PMID9873563	ChEMBL
Kd	9.1 nM	PMID9379432	BindingDB
Kd	9.12 nM	PMID9379432, PMID11384242	ChEMBL
Kd	12.59 nM	PMID25874333	ChEMBL
Ki	0.82 nM	PMID10780916	BindingDB,ChEMBL
Ki	3.9 nM	PMID9548811	BindingDB,ChEMBL
Ki	5.01 nM	PMID7815325	BindingDB
Ki	9.592 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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