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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	L-Homocysteic acid
Molecular formula	C4H9NO5S
IUPAC name	(2S)-2-amino-4-sulfobutanoic acid
Molecular weight	183.178
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-3.6
Synonyms	14857-77-3 CHEBI:132223 KB-53220 SCHEMBL157695 AJ-41531 CHEMBL230951 L-HOMOCYSTEATE YW13F86W9W (S)-2-amino-4-sulfobutanoic acid C16511 FT-0637148 PDSP1_001269 CHEBI:80543 L-2-Amino-4-sulfobutyrate UNII-HYA2G5T79L component VBOQYPQEPHKASR-VKHMYHEASA-N (2S)-2-Amino-4-sulfobutanoic acid BDBM50220147 DB-042945 ZINC2567965 (S)-2-amino-4-sulfobutyric acid CC-29946 H-2740 PDSP2_001253 AC1L42RY L-2-Amino-4-sulfobutyric acid UNII-YW13F86W9W (2S)-2-amino-4-sulfobutyric acid C-24823 FCH838969 MFCD00066018 [ Show all ]
Inchi Key	VBOQYPQEPHKASR-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
PubChem CID	177491
ChEMBL	CHEMBL230951
IUPHAR	N/A
BindingDB	50220147
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12649361	BindingDB

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