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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-1B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1B
Synonym	alpha1B-adrenoceptor alpha1B-adrenergic receptor Alpha-1B adrenoreceptor Alpha-1B adrenoceptor alpha 1B-adrenoreceptor alpha 1B-adrenoceptor adrenergic receptor adrenergic alpha 1B receptor [ Show all ]
Disease	Psychiatric disorder Hypertension Exogenous obesity Attention deficit hyperactivity disorder
Length	520
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
UniProt	P35368
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T29500
ChEMBL	CHEMBL232
IUPHAR	23
DrugBank	BE0000575

Ligand

Name	L-Homocysteic acid
Molecular formula	C4H9NO5S
IUPAC name	(2S)-2-amino-4-sulfobutanoic acid
Molecular weight	183.178
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-3.6
Synonyms	AC1L42RY L-2-Amino-4-sulfobutyric acid UNII-YW13F86W9W C-24823 FCH838969 MFCD00066018 (2S)-2-amino-4-sulfobutyric acid CHEBI:132223 KB-53220 SCHEMBL157695 14857-77-3 AJ-41531 CHEMBL230951 L-HOMOCYSTEATE YW13F86W9W C16511 FT-0637148 PDSP1_001269 (S)-2-amino-4-sulfobutanoic acid CHEBI:80543 L-2-Amino-4-sulfobutyrate UNII-HYA2G5T79L component VBOQYPQEPHKASR-VKHMYHEASA-N BDBM50220147 DB-042945 ZINC2567965 (2S)-2-Amino-4-sulfobutanoic acid CC-29946 H-2740 PDSP2_001253 (S)-2-amino-4-sulfobutyric acid [ Show all ]
Inchi Key	VBOQYPQEPHKASR-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
PubChem CID	177491
ChEMBL	CHEMBL230951
IUPHAR	N/A
BindingDB	50220147
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12649361	BindingDB

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