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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	D-Lysergic acid N,N-diethylamide
Molecular formula	C20H25N3O
IUPAC name	N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	CAS_50-37-3 Ergoline-8.beta.-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- Pearly gates [Street Name] D-LSD-25 L000352 VAYOSLLFUXYJDT-UHFFFAOYSA-N Acid [Street Name] Dextrolysergic Acid diethylamide N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, (8.beta.)- # (+)-LSD COS0000448 Heavenly Blue [Street Name] Royal Blue [Street Name] 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-.beta.-carboxamide d-Lysergic acid dethylamide Lysergsaure diethylamid Wedding bells [Street Name] BDBM86427 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8.beta.)- NSC_3981 Cubes [Street Name] Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. SCHEMBL12401704 AC1L1H5B Lysergsaure-N,N-diethylamid [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3
PubChem CID	3981
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	14.0 nM	Peroutka et al., PMID1989	PDSP

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