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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Homo sapiens (Human)
Gene	HTR1A
Synonym	5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Gpcr18 ADRB2RL1 ADRBRL1 G-21 [ Show all ]
Disease	Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder Major depressive disorder Major depressive disorder; Episode; Anxiety Migraine Mood disorder Pain Parkinson's disease Premature ejaculation Psychiatric disorder Psychotic disorders Schizoaffective disorder; Schizophrenia Severe mood disorders Unspecified Female sexual dysfunction Eating disorder Schizophrenia Alzheimer disease Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis Bulimia nervosa; Severe mood disorders Cervical dystonia; Spasm Cognitive disorders Anxiety disorder Depression Coronary artery disease [ Show all ]
Length	422
Amino acid sequence	MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
UniProt	P08908
Protein Data Bank	N/A
GPCR-HGmod model	P08908
3D structure model	This predicted structure model is from GPCR-EXP P08908.
BioLiP	N/A
Therapeutic Target Database	T78709
ChEMBL	CHEMBL214
IUPHAR	1
DrugBank	BE0000291

Ligand

Name	D-Lysergic acid N,N-diethylamide
Molecular formula	C20H25N3O
IUPAC name	N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	SCHEMBL12401704 Cubes [Street Name] Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. Lysergsaure-N,N-diethylamid AC1L1H5B Pearly gates [Street Name] CAS_50-37-3 Ergoline-8.beta.-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- VAYOSLLFUXYJDT-UHFFFAOYSA-N D-LSD-25 L000352 N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, (8.beta.)- # Acid [Street Name] Dextrolysergic Acid diethylamide Royal Blue [Street Name] (+)-LSD COS0000448 Heavenly Blue [Street Name] Wedding bells [Street Name] 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-.beta.-carboxamide d-Lysergic acid dethylamide Lysergsaure diethylamid NSC_3981 BDBM86427 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8.beta.)- [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3
PubChem CID	3981
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.64 nM	Wander et al., PMID1987	PDSP
Ki	1.09 nM	PMID7984267	PDSP
Ki	1.1 nM	PMID12213075	PDSP
Ki	4.92 nM	Pierce & Peroutka, PMID1989	PDSP

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