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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	Lysergide
Molecular formula	C20H25N3O
IUPAC name	(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	752-EP2289868A1 LSD (Lysergic Acid Diethylamide;Lysergide) Bartman 752-EP2295406A1 Lucy in the Sky with Diamonds Blue Mist 752-EP2298761A1 Lysergidum 752-EP2301918A1 N,N-Diethyl-(+)-Lysergamide Cupcakes 752-EP2305650A1 Orange Wedges (6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide DB04829 752-EP2308838A1 Pearly gates [Street Name] DSSTox_GSID_23231 752-EP2308870A2 Strawberry Fields 752-EP2270004A1 Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2311850A1 UNII-8NA5SWF92O 752-EP2272972A1 Hawk 752-EP2371797A1 Yellows 752-EP2282982A1 Lisergide [DCIT] 8NA5SWF92O AC1L1L2W 752-EP2292589A1 LSD solution, 25 mug/mL in acetonitrile, ampule of 1 mL, certified reference material Beast 752-EP2295411A1 Lysergaure diethylamid Brown Dots 752-EP2298770A1 Lysergsaeurediethylamid Cherry Top 752-EP2301935A1 N,N-Diethyllysergamide d-Lysergic acid dethylamide 752-EP2305666A1 PDSP1_001431 (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide Dextrolysergic Acid diethylamide 752-EP2308848A1 Royal blue 6482-EP2311801A1 EINECS 200-033-2 752-EP2311808A1 The Hawk 752-EP2270016A1 Frogs 752-EP2314587A1 Wedding Bells Acid 752-EP2275411A2 Heavenly Blue [Street Name] 752-EP2371804A1 [N-methyl-3H]LSD 752-EP2284178A2 LS-64351 LSD (Lysergic Acid Diethylamide) 0.025 mg/ml in Acetonitrile Barrels 752-EP2292624A1 LSD-25 Blue Acid 752-EP2298736A1 CAS-50-37-3 752-EP2298783A1 Mellow Yellow Clearlight Cubes 752-EP2305640A2 Orange Mushroom (4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide D0M7LV 752-EP2305685A1 PDSP2_001524 4-25-00-00939 (Beilstein Handbook Reference) Domes 752-EP2308861A1 SCHEMBL113755 6482-EP2371814A1 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- 752-EP2311834A1 Trippers 752-EP2272834A1 Greenies 752-EP2316832A1 White Light 752-EP2277872A1 Instant Zen 752-EP2377849A2 752-EP2287153A1 752-EP2289885A1 LSD 25 BDBM21342 752-EP2295407A1 Lysergamid Blue Star 752-EP2298763A1 Lysergidum [INN-Latin] CHEMBL263881 752-EP2301928A1 N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide D-Lsd 752-EP2305652A2 Owsley (8alpha)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8-Carboxamide DEA No. 7315 752-EP2308839A1 Purple Haze 6482-EP1441224A2 DSSTox_RID_76934 752-EP2308871A1 Sugar Lump 752-EP2270006A1 Fifty 752-EP2314571A2 VAYOSLLFUXYJDT-RDTXWAMCSA-N 752-EP2272973A1 Haze 752-EP2371798A1 ZINC96903803 752-EP2284162A2 Lisergido 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide LSD Acid [Street Name] 752-EP2292613A1 LSD,(+) Big F 752-EP2298731A1 LYSERGIC ACID DIETHYLAMIDE C07542 752-EP2298772A1 Lysergsauerediaethylamid Chief 752-EP2301937A1 NCGC00168265-01 (+)-LSD D-Lysergic acid diethylamide 752-EP2305673A1 PDSP1_001540 Diethylamid kyseliny lysergove 752-EP2308849A1 Royal Blue [Street Name] 6482-EP2311802A1 Ergoline-8-beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2311825A1 Tox21_112872 752-EP2272537A2 FT-0670891 752-EP2316470A2 Wedding bells [Street Name] 752-EP2275417A2 HSDB 3920 752-EP2374786A1 752-EP2284179A2 752-EP2287155A1 LSD (Lysergic Acid Diethylamide) 1.0 mg/ml in Acetonitrile Bart Simpson 752-EP2295402A2 LSD-25, lysergidD Blue Cheer 752-EP2298745A1 Lysergide [INN:BAN:DCF] CHEBI:6605 752-EP2301627A1 Microdots Cubes [Street Name] 752-EP2305648A1 Orange Sunshine (6aR,9R)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 752-EP2305686A1 Pearly gates 50-37-3 DSSTox_CID_3231 752-EP2308867A2 Spoonies 752-EP2269986A1 Ergoline-8b-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- (8CI) 752-EP2311842A2 Ubergluben 752-EP2272842A1 GTPL17 752-EP2316833A1 Window Pane 752-EP2281812A1 Lisergide 7LD 752-EP2292228A1 LSD solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material BDBM50241702 752-EP2295410A1 Lysergamide, N,N-diethyl- BRN 0094179 752-EP2298767A1 Lysergsaeurediaethylamid CHEMBL463207 752-EP2301929A1 N,N-Diethyl-D-lysergamide D-LSD-25 752-EP2305663A1 Paper Acid (8beta)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide Delysid 752-EP2308847A1 Purple Microdot 6482-EP2311494A1 DTXSID1023231 752-EP2308873A1 Sunshine 752-EP2270014A1 Flats 752-EP2314581A1 Wedding bells 752-EP2275403A1 Heavenly Blue 752-EP2371800A1 [3H]-LSD 752-EP2284163A2 Lisergido [INN-Spanish] 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide LSD (alkaloid) AKOS028112397 752-EP2292619A1 LSD,l- Blotter Acid 752-EP2298735A1 Lysergic acid diethylamide-25 California Sunshine 752-EP2298777A2 Mean Green Chocolate Chips Contact Lens 752-EP2305033A1 NCGC00168265-02 (+)-Lysergic acid diethylamide D-Lysergic acid N,N-diethylamide 752-EP2305674A1 PDSP2_001415 Diethylamid kyseliny lysergove [Czech] 752-EP2308850A1 Scapes 6482-EP2311803A1 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8b)- 752-EP2311829A1 Tox21_113508 752-EP2272822A1 Gelatin Chips 752-EP2316831A1 Wedges 752-EP2277866A1 Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. 752-EP2374787A1 752-EP2286811A1 [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-RDTXWAMCSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
PubChem CID	5761
ChEMBL	CHEMBL263881
IUPHAR	17
BindingDB	50241702, 21342
DrugBank	DB04829
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.86 nM	PMID9225298	BindingDB
Ki	1.99526 - 15.8489 nM	PMID9225298, PMID9730917	IUPHAR
Ki	16.59 nM	PMID9225298	BindingDB

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