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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	Lysergide
Molecular formula	C20H25N3O
IUPAC name	(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	Heavenly Blue [Street Name] 752-EP2311829A1 752-EP2272822A1 [N-methyl-3H]LSD LS-64351 752-EP2316831A1 752-EP2277866A1 LSD solution, 25 mug/mL in acetonitrile, ampule of 1 mL, certified reference material 752-EP2374787A1 752-EP2286811A1 Lysergaure diethylamid AKOS028112397 752-EP2292619A1 Lysergsaeurediethylamid Blotter Acid 752-EP2298735A1 N,N-Diethyllysergamide California Sunshine d-Lysergic acid dethylamide 752-EP2298777A2 PDSP1_001431 Chocolate Chips Dextrolysergic Acid diethylamide 752-EP2305033A1 (+)-Lysergic acid diethylamide Royal blue EINECS 200-033-2 752-EP2305674A1 The Hawk Frogs 752-EP2308850A1 6482-EP2311803A1 Wedding Bells Acid 752-EP2270004A1 White Light Instant Zen 752-EP2311850A1 752-EP2272972A1 LSD (Lysergic Acid Diethylamide) 0.025 mg/ml in Acetonitrile 752-EP2371797A1 752-EP2282982A1 LSD-25 8NA5SWF92O 752-EP2289868A1 Bartman 752-EP2295406A1 Mellow Yellow Blue Mist Cubes 752-EP2298761A1 Orange Mushroom D0M7LV 752-EP2301918A1 PDSP2_001524 Domes 752-EP2305650A1 (6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide SCHEMBL113755 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- 752-EP2308838A1 Trippers Greenies 752-EP2308870A2 752-EP2311808A1 752-EP2270016A1 ZINC96903803 Lisergido 752-EP2314587A1 752-EP2275411A2 LSD 25 752-EP2371804A1 752-EP2284178A2 Lysergamid AC1L1L2W 752-EP2292589A1 Lysergidum [INN-Latin] Beast 752-EP2295411A1 N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide Brown Dots D-Lsd 752-EP2298770A1 Owsley Cherry Top DEA No. 7315 752-EP2301935A1 Purple Haze DSSTox_RID_76934 752-EP2305666A1 (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide Sugar Lump Fifty 752-EP2308848A1 6482-EP2311801A1 VAYOSLLFUXYJDT-RDTXWAMCSA-N Haze HSDB 3920 752-EP2311834A1 752-EP2272834A1 LSD 752-EP2316832A1 752-EP2277872A1 LSD,(+) 752-EP2377849A2 752-EP2287153A1 LYSERGIC ACID DIETHYLAMIDE Barrels 752-EP2292624A1 Lysergsauerediaethylamid Blue Acid 752-EP2298736A1 NCGC00168265-01 CAS-50-37-3 D-Lysergic acid diethylamide 752-EP2298783A1 PDSP1_001540 Clearlight Diethylamid kyseliny lysergove 752-EP2305640A2 (4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide Royal Blue [Street Name] Ergoline-8-beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2305685A1 4-25-00-00939 (Beilstein Handbook Reference) Tox21_112872 FT-0670891 752-EP2308861A1 6482-EP2371814A1 Wedding bells [Street Name] 752-EP2270006A1 Window Pane Lisergide 752-EP2314571A2 752-EP2272973A1 LSD (Lysergic Acid Diethylamide) 1.0 mg/ml in Acetonitrile 752-EP2371798A1 752-EP2284162A2 LSD-25, lysergidD 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide 752-EP2289885A1 Lysergide [INN:BAN:DCF] BDBM21342 752-EP2295407A1 Microdots Blue Star Cubes [Street Name] 752-EP2298763A1 Orange Sunshine CHEMBL263881 752-EP2301928A1 Pearly gates DSSTox_CID_3231 752-EP2305652A2 (8alpha)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8-Carboxamide Spoonies Ergoline-8b-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- (8CI) 752-EP2308839A1 6482-EP1441224A2 Ubergluben GTPL17 752-EP2308871A1 Heavenly Blue 752-EP2311825A1 752-EP2272537A2 [3H]-LSD Lisergido [INN-Spanish] 752-EP2316470A2 752-EP2275417A2 LSD solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material 752-EP2374786A1 752-EP2284179A2 Lysergamide, N,N-diethyl- Acid [Street Name] 752-EP2292613A1 Lysergsaeurediaethylamid Big F 752-EP2298731A1 N,N-Diethyl-D-lysergamide C07542 D-LSD-25 752-EP2298772A1 Paper Acid Chief Delysid 752-EP2301937A1 (+)-LSD Purple Microdot DTXSID1023231 752-EP2305673A1 Sunshine Flats 752-EP2308849A1 6482-EP2311802A1 Wedding bells Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. 752-EP2311842A2 752-EP2272842A1 LSD (alkaloid) 752-EP2316833A1 752-EP2281812A1 LSD,l- 7LD 752-EP2287155A1 Lysergic acid diethylamide-25 Bart Simpson 752-EP2295402A2 Mean Green Blue Cheer Contact Lens 752-EP2298745A1 NCGC00168265-02 CHEBI:6605 D-Lysergic acid N,N-diethylamide 752-EP2301627A1 PDSP2_001415 Diethylamid kyseliny lysergove [Czech] 752-EP2305648A1 (6aR,9R)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide Scapes Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8b)- 752-EP2305686A1 50-37-3 Tox21_113508 Gelatin Chips 752-EP2308867A2 752-EP2269986A1 Wedges 752-EP2270014A1 Yellows Lisergide [DCIT] 752-EP2314581A1 752-EP2275403A1 LSD (Lysergic Acid Diethylamide;Lysergide) 752-EP2371800A1 752-EP2284163A2 Lucy in the Sky with Diamonds 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide 752-EP2292228A1 Lysergidum BDBM50241702 752-EP2295410A1 N,N-Diethyl-(+)-Lysergamide BRN 0094179 Cupcakes 752-EP2298767A1 Orange Wedges CHEMBL463207 DB04829 752-EP2301929A1 Pearly gates [Street Name] DSSTox_GSID_23231 752-EP2305663A1 (8beta)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide Strawberry Fields Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- 752-EP2308847A1 6482-EP2311494A1 UNII-8NA5SWF92O Hawk 752-EP2308873A1 [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-RDTXWAMCSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
PubChem CID	5761
ChEMBL	CHEMBL263881
IUPHAR	17
BindingDB	21342, 50241702
DrugBank	DB04829
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	52.84 nM	PMID17067154	BindingDB
Ki	2.51189 - 6.30957 nM	PMID10611640	IUPHAR
Ki	5.012 nM	PMID14613313	ChEMBL
Ki	45.71 nM	PMID10498829	BindingDB

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