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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	Ifenprodil
Molecular formula	C21H27NO2
IUPAC name	4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
Molecular weight	325.452
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.9
Synonyms	Creocral DSSTox_RID_81034 Ifenprodil (INN) J-015034 NCGC00024643-05 RC 61-91 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine) Tox21_110915 23210-58-4 925913-11-7 C-19841 D0I0DL FT-0601591 ifenprodil tartrate LS-115339 NCGC00024643-10 SCHEMBL34010 1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)- (9CI) UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Alpha 1-PI CCG-204747 CHEMBL305187 DSSTox_CID_25656 I06-0297 Ifenprodilum NCGC00024643-03 PDSP2_000646 (+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol] SR-01000075169-11 210I562 4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol BDBM50083351 D08064 DTXSID2045656 IFENPRODIL HEMITARTRATE KB-52538 NCGC00024643-06 RC-61-91 1-Piperidineethanol, 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl- Tox21_110915_1 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol AC1L1GHT CAS-23210-56-2 DB08954 GTPL5472 Ifenprodil tartrate salt MRF-0000097 NCGC00024643-12 SR-01000075169 2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol Vadilex 4-[2-(4-Benzyl-1-piperidyl)-1-hydroxy-propyl]phenol; (2R,3R)-2,3-dihydroxybutanedioic acid alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol CHEBI:93829 ChEMBL_104385 DSSTox_GSID_45656 Ifenprodilum [INN-Latin] NCGC00024643-04 R8OE3P6O5S (plusmn)-ifenprodil SR-01000075169-3 23210-56-2 61 91 RC BRD-A24191444-045-03-1 D08VCI EINECS 245-491-4 Ifenprodil L-(+)-tartrate L005364 NCGC00024643-07 SBI-0050640.P002 1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)- UNII-R8OE3P6O5S 4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol AKOS015895174 CC-29467 Dilvax HMS2089G05 Ifenprodil [INN:DCF] NCGC00024643-02 PDSP1_000654 SR-01000075169-1 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol AX8042605 [ Show all ]
Inchi Key	UYNVMODNBIQBMV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
PubChem CID	3689
ChEMBL	CHEMBL305187
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1000.0 nM	PMID1681106	ChEMBL

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