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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 5
Species	Homo sapiens (Human)
Gene	SSTR5
Synonym	SOMATO SS-5-R SS5-R SS5R SST5 receptor
Disease	N/A
Length	364
Amino acid sequence	MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
UniProt	P35346
Protein Data Bank	N/A
GPCR-HGmod model	P35346
3D structure model	This predicted structure model is from GPCR-EXP P35346.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1792
IUPHAR	359
DrugBank	BE0002147

Ligand

Name	cycloantagonist SA
Molecular formula	C42H55N7O5
IUPAC name	(3S,6S,9R,12S)-6-(4-aminobutyl)-12-benzyl-9-(1H-indol-3-ylmethyl)-3-[(1R)-1-phenoxyethyl]-1,4,7,10,13-pentazacyclononadecane-2,5,8,11-tetrone
Molecular weight	737.946
Hydrogen bond acceptor	7
Hydrogen bond donor	7
XlogP	4.8
Synonyms	c[Aha-Phe-D-Trp-Lys-Thr(Bzl)] BDBM82471
Inchi Key	UYLQYUAFNNCEIJ-GGMHJNBLSA-N
Inchi ID	InChI=1S/C42H55N7O5/c1-29(54-32-18-8-5-9-19-32)38-42(53)45-25-15-3-2-14-24-44-36(26-30-16-6-4-7-17-30)40(51)48-37(27-31-28-46-34-21-11-10-20-33(31)34)41(52)47-35(39(50)49-38)22-12-13-23-43/h4-11,16-21,28-29,35-38,44,46H,2-3,12-15,22-27,43H2,1H3,(H,45,53)(H,47,52)(H,48,51)(H,49,50)/t29-,35+,36+,37-,38+/m1/s1
PubChem CID	57339675
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82471
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.62 nM	PMID10598788, PMID9652348	BindingDB
Ki	16.98 nM	PMID10598788, PMID9652348	BindingDB
Ki	316.22 nM	PMID8769372	BindingDB
Ki	416.86 nM	PMID10598788, PMID9652348	BindingDB
Ki	416.87 nM	PMID9650799	BindingDB
Ki	954.99 nM	PMID10598788, PMID9650799	BindingDB
Ki	1000.0 nM	PMID8102785	BindingDB

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