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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Homo sapiens (Human)
Gene	GRM6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A
Length	877
Amino acid sequence	MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
UniProt	O15303
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4573
IUPHAR	294
DrugBank	N/A

Ligand

Name	MLS000530551
Molecular formula	C15H14Cl2N2O3S
IUPAC name	2-(2-chloro-N-methylsulfonylanilino)-N-(3-chlorophenyl)acetamide
Molecular weight	373.248
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	HMS2419O15 N~2~-(2-chlorophenyl)-N~1~-(3-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide ZINC1208360 AKOS001650116 SR-01000461844 2-(2-chloro-N-mesyl-anilino)-N-(3-chlorophenyl)acetamide cid_1364364 N-(3-chlorophenyl)-2-[(2-chlorophenyl)-methylsulfonyl-amino]ethanamide vu0034403 BDBM44464 KB-276103 Oprea1_197705 CHEMBL1451902 MLS004580681 SR-01000461844-1 2-(2-chloro-N-methylsulfonylanilino)-N-(3-chlorophenyl)acetamide HMS1479E10 N~2~-(2-chlorophenyl)-N-(3-chlorophenyl)-N~2~-(methylsulfonyl)glycinamide VU0034403-6 AC1LR8N5 BRD-K57697154-001-01-2 MCULE-6953859399 SMR000135531 ChemDiv3_002210 MolPort-003-183-853 STL120932 358360-83-5 [ Show all ]
Inchi Key	UUYQFOSWDVZCAB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19(14-8-3-2-7-13(14)17)10-15(20)18-12-6-4-5-11(16)9-12/h2-9H,10H2,1H3,(H,18,20)
PubChem CID	1364364
ChEMBL	CHEMBL1451902
IUPHAR	N/A
BindingDB	44464
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	<10.0 uM	PMID23142615	ChEMBL

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