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Name | Proteinase-activated receptor 1 |
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Species | Homo sapiens (Human) |
Gene | F2R |
Synonym | Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor [ Show all ] |
Disease | Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis [ Show all ] |
Length | 425 |
Amino acid sequence | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT |
UniProt | P25116 |
Protein Data Bank | 3vw7 |
GPCR-HGmod model | P25116 |
3D structure model | This structure is from PDB ID 3vw7. |
BioLiP | BL0217099 |
Therapeutic Target Database | T36483 |
ChEMBL | CHEMBL3974 |
IUPHAR | 347 |
DrugBank | BE0000928 |
Name | CHEMBL3143281 |
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Molecular formula | C48H65F2N15O7 |
IUPAC name | (2S)-2-[[(2S)-2-[[(2S)-2-[acetyl-[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-3-[4-(diaminomethylideneamino)phenyl]propanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide |
Molecular weight | 1002.14 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 11 |
XlogP | 0.7 |
Synonyms | N/A |
Inchi Key | BWMRBTPHIRCUQQ-NABVGGPWSA-N |
Inchi ID | InChI=1S/C48H65F2N15O7/c1-27(2)24-37(43(70)62-36(7-5-23-59-47(54)55)42(69)61-35(41(51)68)6-4-22-58-46(52)53)63-44(71)38(25-30-12-19-34(20-13-30)60-48(56)57)64-45(72)39(26-31-10-17-33(50)18-11-31)65(28(3)66)40(67)21-14-29-8-15-32(49)16-9-29/h8-21,27,35-39H,4-7,22-26H2,1-3H3,(H2,51,68)(H,61,69)(H,62,70)(H,63,71)(H,64,72)(H4,52,53,58)(H4,54,55,59)(H4,56,57,60)/b21-14+/t35-,36-,37-,38-,39-/m0/s1 |
PubChem CID | 90663319 |
ChEMBL | CHEMBL3143281 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 19.0 nM | PMID8960546 | ChEMBL |
IC50 | 50.0 nM | PMID8960546 | ChEMBL |
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