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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL380504
Molecular formulaC22H21F3N2O2S
IUPAC name2-methyl-3-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylamino]phenyl]propanoic acid
Molecular weight434.477
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP5.7
SynonymsN/A
Inchi KeyAEGXQTLIMRGLHO-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H21F3N2O2S/c1-13(21(28)29)11-15-3-9-18(10-4-15)26-12-19-14(2)27-20(30-19)16-5-7-17(8-6-16)22(23,24)25/h3-10,13,26H,11-12H2,1-2H3,(H,28,29)
PubChem CID44409729
ChEMBLCHEMBL380504
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
%max100.0 %PMID16439116ChEMBL
EC50354.81 nMPMID16439116ChEMBL

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